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Table 5 Inheritance and transmission rules.

From: Haplotype association analyses in resources of mixed structure using Monte Carlo testing

Rule

Description

Inheritance

Indicates which haplotype is received by the offspring (characteristic of offspring haplotypes).

 

The parental source of an offspring haplotype can be established using exclusion. That is, once an offspring haplotype is known not to be from one parent, it is must be from the other parent.

 

Exclusion can be determined if a haplotype has an allele not found within a parent's genotypes or the haplotype does not match either of a parent's set haplotypes.

Transmission

Indicates which haplotype is transmitted by the parent (characteristic of parental haplotypes).

 

Which haplotype is transmitted from a parent to an offspring can be established using exclusion. That is, once a parental haplotype is excluded as being either haplotype in an offspring, then the alternate parental haplotype must be the transmitted one.

 

A conditional exclusion can be determined by examining the situation where one parental haplotype was transmitted to the offspring and check if the complimentary haplotype from the offspring's genotypes could be inherited from the other parent.