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Figure 1 | BMC Bioinformatics

Figure 1

From: Haplotype association analyses in resources of mixed structure using Monte Carlo testing

Figure 1

Example of a parent-to-offspring homozygous update using bit-variables. The parent's homozygous variable (homparent) is used to update variables in the offspring. In this example, offspring haplotype 1 has been chosen for update. Variables listed on the left in the trio drawing are the current states for the offspring and parent. Variables listed in the panel on the right and indicated by (new) are the updated states. Panel A. Logical "AND" operation determines which loci are homozygous in the parent and unphased in the offspring. The result (a.) indicates positions (value = 1) where updates can be made to the setoffspring, valueoffspring and unphasedoffspring variables. In this example, 3 positions can be updated (the 5th, 8th and 9th). Panel B. Similar to panel A, but for the missingoffspring variable. In this example, no positions can be updated for this variable (all position in b. = 0). Panels C-E. Logical operations "OR", exclusive OR ("XOR") and "AND" are used to determine the new updated versions of variables setoffspring, unphasedoffspring and valueoffspring.

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