Compartmentalization of the Edinburgh Human Metabolic Network

BMC Bioinformatics

Table 3 Sub-cellular location comparison of Human Recon 1, EHMN, and Reactome database

	Human Recon 1^a	Reactome^b	EHMN
Metabolic reactions	2147	809(998)^c	3381 (4793)^d
Extracellular	53	52	234
Nucleus	87	6	226
Cytosol	957	440(629)^c	892 (2304)^d
Endoplasmic reticulum	187	64	649
Golgi apparatus	253	1	241
Peroxisomes	92	43	291
Lysosomes	190	0	108
Mitochondria	328	203	740
Non-repeat metabolic reactions^e	1836	998	2806
Transport reactions	1190 (1596)^f	218	1423

^a the numbers is based on the data downloaded from BIGG database and may be different from those in their published paper. ^b the metabolic reactions from Reactome include metabolism of amino acids and derivatives, carbohydrates, nitric oxide, nucleotides, polyamines, porphyrins, vitamins and cofactors, pyruvate and citric acid cycle, lipids and lipoproteins, energy, biological oxidations and electron transport chain. The transport reactions include membrane trafficking and transmembrane transport of small molecules pathways. ^c the number in the parentheses includes the reactions which were assigned to "cytosol" from unclear location or locations other than the chosen ones. ^d the number in the parentheses includes the reaction which are assigned to "cytosol" from "uncertain". ^e a reaction occurs in different locations was counted only once. ^f the number in the parentheses includes the exchange reactions.

ISSN: 1471-2105