Table 1 Illustration of the empirical FWER based on a nominal two-sided 0.05 level, with m= 200 genes, N= 200 simulation samples and B= 200 resampling replications per sample. The outlier law realizes values -4,0 or 4 with probabilities π/2, 1 - π and π/2 respectively. Under simulation model 1, the outlier effect is added to all time-points. Under simulation model 2, the outlier effect is only added to the first and last time-points.
From: Robust test method for time-course microarray experiments
Simulation 1 | Simulation 2 | ||||||
|---|---|---|---|---|---|---|---|
π | ρ |
|
|
|
|
|
|
0 | 0 | 0.035 | 0.060 | 0.060 | |||
0.3 | 0.040 | 0.035 | 0.035 | ||||
0.6 | 0.040 | 0.040 | 0.040 | ||||
0.05 | 0 | 0.040 | 0.040 | 0.040 | 0.065 | 0.075 | 0.155 |
0.3 | 0.040 | 0.055 | 0.055 | 0.050 | 0.065 | 0.160 | |
0.6 | 0.060 | 0.045 | 0.055 | 0.075 | 0.055 | 0.130 | |
0.1 | 0 | 0.035 | 0.040 | 0.050 | 0.035 | 0.040 | 0.355 |
0.3 | 0.040 | 0.045 | 0.055 | 0.050 | 0.075 | 0.355 | |
0.6 | 0.060 | 0.045 | 0.045 | 0.050 | 0.055 | 0.295 | |
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-PERM