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Table 3 Scoring methods at an alignment site k

From: A comparative study of conservation and variation scores

Symbol frequency

S

Wu70

d k /p k (α0(k))

 

I

Lockless99

 

S

Pei01var(w)

Stereochemical properties

I

Taylor86

min|{T j :A k ⊆ T j }|, j = 1,...,61

 

I

Zvelebil87

0.9 - 0.1n dis

Symbol entropy

S

Sander91

S20(p k )

 

S

Shenkin91

 

S

Gerstein95

S2(p k ) - S2(p)

 

I

Wang06w

R(p k , q)

 

I

Capra07w

(R(p k , r) + R(q, r))/2, r = (p k + q)/2

Stereochemically sensitive entropy

S

Mirny99

S e (p k ), AA = {AVLIMC, FWYH, STNQ, KR, DE, GP}

 

S

Williamson95

R(p k , p), AA = {VLIM, FWY, ST, NQ, HKR, DE, AG, P, C}

 

S

Caffrey04w

V(p k )

Substitution matrix

S

Sander91sp

 

I

Karlin96

 

S

Valdar01

 

S

Pei01sp(w)

 

I

Thompson97

 

I

Mihalek07

 

I

Liu08w

Phylogeny

S

Mihalek04

 

I

Zhang08

 

D

Mayrose04

Rate4Site

  1. Methods labeled as S: available in SEALA package at http://github.com/fredrikj, I: implemented for this study and available at http://github.com/fredrikj/bioruby, D: downloaded from the Rate4Site website http://consurf.tau.ac.il. Scores ending with "w" use sequence weighting by Henikoff and Henikoff [9]. Scores ending with "(w)" are used both with and without weights. Explanation of notations are given in Table 4, and further details can be found in the main text.