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Table 1 Enrichment tests for the list of 287 genes and 688 genes

From: A factor model to analyze heterogeneity in gene expression

LIST OF 287 GENES

GOID

GO Term

Size

Count

Pvalue

HGNC ID

GO.0006470

protein amino acid dephosphorylation

56

5

0.015

ACP1, PTPN14, PTPRE, PTP4A3, PTPN6

GO.0006725

cellular aromatic compound metabolic process

38

4

0.017

PPME1, GART, MOCS1, ALDH6A1

GO.0007259

JAK STAT cascade

9

2

0.022

SOCS1, STAMBP

GO.0043543

protein amino acid acylation

9

2

0.022

NULL, ZDHHC17

GO.0044259

multicellular macromolecule metabolic process

10

2

0.027

ACE2, SERPINH1

GO.0008033

tRNA processing

26

3

0.0296

TSEN15, FARS2, NSUN2

GO.0033002

muscle cell proliferation

11

2

0.032

NOX1, BMP10

GO.0050730

regulation of peptidyl tyrosine phosphorylation

12

2

0.038

SOCS1, EGFR

Kegg ID

Kegg pathway

Size

Count

Pvalue

HGNC ID

map04320

Dorso ventral axis formation

9

3

2.38E-03

EGFR, SPIRE1, ETS1

LIST OF 688 GENES

GOID

GO Term

Size

Count

Pvalue

HGNC ID

GO.0006470

protein amino acid dephosphorylation

56

10

1.80E-03

ACP1, PPM1E, PTPN14, PTPRE, PTP4A3, PPM1G, PTPRU, PPP3CB, PPM1L, PTPRF

GO.0046483

heterocycle metabolic process

33

7

3.21E-03

AMBP, GART, P4HA2, HMOX2, AFMID, MTHFS, ALDH6A1

GO.0051186

cofactor metabolic process

64

10

4.97E-03

AMBP, TXNRD3, NOX1, HMOX2, AFMID, GGT7, MTHFS, MOCS1, HMGCS1, ACO2

GO.0016202

regulation of striated muscle development

15

4

0.011

MBNL3, LEF1, NRG1, BMP4

GO.0007259

JAK STAT cascade

9

3

0.014

SOCS1, HCLS1, STAMBP

GO.0040011

locomotion

111

13

0.017

PRKG1, EDNRB, ACE2, NOX1, EGFR, NRG1, BMP10, ARAP3, JPH3, VHL, VAX1, DAB1, LAMA2

GO.0001932

regulation of protein amino acid phosphorylation

26

5

0.019

PDGFA, SOCS1, HCLS1, EGFR, BMP4

GO.0048585

negative regulation of response to stimulus

10

3

0.020

AMBP, PPP3CB, FABP7

GO.0006534

cysteine metabolic process

4

2

0.021

CBS, CDO1

GO.0002274

myeloid leukocyte activation

11

3

0.026

IRF4, LCP2, NDRG1

GO.0006725

cellular aromatic compound metabolic process

38

6

0.026

PPME1, GART, AFMID, MTHFS, MOCS1, ALDH6A1

GO.0007185

transmembrane receptor tyrosine phosphatase signaling

5

2

0.033

PTPRE, PTPRF

GO.0007271

synaptic transmission cholinergic

5

2

0.033

CHRNA4, LAMA2

GO.0000097

sulfur amino acid biosynthetic process

5

2

0.033

CBS, CDO1

GO.0006700

C21 steroid hormone biosynthetic process

5

2

0.033

STAR, CYP17A1

GO.0006787

porphyrin catabolic process

5

2

0.033

AMBP, HMOX2

GO.0001764

neuron migration

12

3

0.033

PRKG1, VAX1, DAB1

GO.0030509

BMP signaling pathway

21

4

0.036

SOSTDC1, BMP10, MSX2, BMP4

GO.0045321

leukocyte activation

64

8

0.040

SWAP70, CHRNA4, FKBP1B, IRF4, LCP2, PPP3CB, NDRG1, SFRS17A

GO.0006790

sulfur metabolic process

32

5

0.043

CBS, CDO1, TXNRD3, GGT7, CHST1

GO.0018193

peptidyl amino acid modification

43

6

0.045

PDGFA, SOCS1, P4HA2, HCLS1, EGFR, MAP2

GO.0008211

glucocorticoid metabolic process

6

2

0.048

STAR, CYP17A1

GO.0006769

nicotinamide metabolic process

6

2

0.048

NOX1, AFMID

GO.0030111

regulation of Wnt receptor signaling pathway

14

3

0.050

SENP2, LEF1, SENP2

Kegg ID

Kegg pathway

Size

Count

Pvalue

HGNC ID

map00630

Glyoxylate and dicarboxylate metabolism

9

4

1.87E-03

GLYCTK, HYI, AFMID, ACO2

map00140

C21 Steroid hormone metabolism

6

3

5.11E-03

DHCR7, HSD11B1, CYP17A1

map04320

Dorso ventral axis formation

9

3

0.018

EGFR, SPIRE1, ETS1

map04012f

ErbB signaling pathway

35

6

0.026

PIK3R5, PLCG1, PAK3, EGFR, NRG1, PTK2

  1. Enrichment tests were performed using an R program (see Methods section) with GO BP terms and Kegg pathways. The tests were done on the list of 287 genes found using the classical approach and the list of 688 genes found by FAMT. For each enriched term, the identifier (ID), the biological term, the size of the whole list of genes related to the term (size), the number of genes in the sub-list related to the term (count), the pvalue of the test and the HGNC Hugo abbreviations of the related genes are given. Italic terms are those which are present in both lists.