Table 1 A comparison of human pathways in HPD against several common pathway data sources.
From: HPD: an online integrated human pathway database enabling systems biology studies
| Â | Â | BioCarta1 | HumanCyc2 | KEGG3 | Reactome4 | PID5 | Protein Lounge6 | HPD |
|---|---|---|---|---|---|---|---|---|
Quality | Scope of Content | Metabolic and signaling pathways | Metabolic Pathways | Metabolic, Regulatory, signaling, disease and drug pathways | Metabolic, signaling and regulatory pathways | Signaling and regulatory pathways | Metabolic, signaling and regulatory pathways | Metabolic, signaling and regulatory pathways |
| Â | Curation Type | Manual | Manual and Computational Prediction | Manual | Manual | Manual | Manual | Integrated from Manually curated database |
Coverage | Human Pathways | 354 | 327 | 205 | 960 | 87 | 427 | 999 |
| Â | Events | > 3000 | > 1500 | 4149 | 3203 | 5232 | NA | 16271 |
Functionality | Related Pathways | No | No | Yes | No | No | No | Yes |
| Â | Multiple Protein Search | No | No | No | No | Yes | No | Yes |
| Â | Pathway-Protein Association Table | No | No | No | No | No | No | Yes |
| Â | Pathway-Pathway Similarity Network | No | No | No | No | No | No | Yes |