Table 7 List of abbreviations used in this study.

COBRA

Constraint-based reconstruction and analysis

EM

Elementary flux mode

CoSet

Correlated reaction set

RBC

Human Red Blood Cell

ExPa

Extreme pathway

AKG

Alpha ketoglutarate

MAL

Malate

GLC

Glucose

G6P

Glucose-6-phosphate

F6P

Fructose-6-phosphate

FDP

Fructose-1,6-phosphate

DHAP

Dihydroxyacetone phosphate

GA3P

Glyceraldehyde-3-phosphate

13DPG

1,3-Diphosphoglycerate

23DPG

2,3-Diphosphoglycerate

3PG

3-Phosphoglycerate

2PG

2-Phosphoglycerate

PEP

Phosphoenolpyruvate

PYR

Pyruvate

LAC

Lactate

6PGL

6-Phosphogluco-lactone

6PGC

6-Phosphogluconate

RL5P

Ribulose-5-phosphate

X5P

Xylulose-5-phosphate

R5P

Ribose-5-phosphate

S7P

Sedoheptulose-7-phosphate

E4P

Erythrose-4-phosphate

PRPP

5-Phosphoribosyl-1-pyrophosphate

IMP

Inosine monophosphate

R1P

Ribose-1-phosphate

HX

Hypoxanthine

INO

Inosine

ADE

Adenine

ADO

Adenosine

AMP

Adenosine monophosphate

ADP

Adenosine diphosphate

ATP

Adenosine triphosphate

NAD

Nicotinamide adenine dinucleotide

H

Hydrogen Ion

NADH

Nicotinamide adenine dinucleotide(R)

NH3

Ammonia

NADP

Nicotinamide adenine dinucleotide phosphate

Pi

Inorganic Phosphate

NADPH

Nicotinamide adenine dinucleotide phosphate(R)

CO2

Carbon Dioxide

H2O

Water

EMP

Embden-Meyerhof-Parnas pathway

PPP

Pentose Phosphate Pathway

34HPPt2m

3 4 hydroxyphenyl pyruvate mitochondrial transport via proton symport

ACKr

acetate kinase

ACOTAim

acteylornithine transaminase irreversible mitochondrial

ACONT

aconitase

ACt2r

acetate reversible transport via proton symport

ABTA

4 aminobutyrate transaminase

AGPRim

N acetyl g glutamyl phosphate reductase irreversible mitochondrial

ACSm

acetyl CoA synthetase

AKGDbm

oxoglutarate dehydrogenase dihydrolipoamide S succinyltransferase

ADHEr

Acetaldehyde dehydrogenase

ACGKm

acetylglutamate kinase mitochondrial

ALD

Aldolase

AKGDam

oxoglutarate dehydrogenase lipoamide

ADK1m

adenylate kinase mitochondrial

AdPRT

Adenine phosphoribosyl transferase

ADK1

adenylate kinase

AKGMAL

alpha ketoglutaratemalate transporter

AKGDH

2 Oxogluterate dehydrogenase

AKGt2r

2 oxoglutarate reversible transport via symport

ARGSL

argininosuccinate lyase

ARGSSr

argininosuccinate synthase reversible

ACLSm

acetolactate synthase mitochondrial

CYOR_u6m

ubiquinol 6 cytochrome c reductase

CS

citrate synthase

CYOOm

cytochrome c oxidase mitochondrial

CO2t

CO2 transporter via diffusion

CYTBD

cytochrome oxidase bd ubiquinol 8 2 protons

CYTK2

cytidylate kinase dCMP

D_LACt2

D lactate transport via proton symport

DCTPD

dCTP deaminase

DHAD1m

dihydroxy acid dehydratase 2 3 dihydroxy 3 methylbutanoate mitochondrial

EN

Enolase

ETOHt2r

ethanol reversible transport via proton symport

ENO

enolase

EX_ac(e)

Acetate exchange

EX_ADE

ADE exchange

EX_akg(e)

2 Oxoglutarate exchange

EX_co2(e)

CO2 exchange

EX_etoh(e)

Ethanol exchange

EX_for(e)

Formate exchange

EX_fum(e)

Fumarate exchange

EX_glc(e)

D Glucose exchange

EX_h2o(e)

H2O exchange

EX_LAC

LAC exchange

EX_lac_D(e)

D lactate exchange

EX_NAD

NAD exchange

EX_NADH

NADH exchange

EX_NADP

NADP exchange

EX_NADPH

NADPH exchange

EX_pyr(e)

Pyruvate exchange

FBA

fructose bisphosphate aldolase

EX_o2(e)

O2 exchange

FORt

formate transport via diffusion

G6PDH2r

glucose 6 phosphate dehydrogenase

GCCam

glycine cleavage complex lipoylprotein mitochondrial

GND

phosphogluconate dehydrogenase

GCCcm

glycine cleavage complex lipoylprotein mitochondrial

GLCpts

D glucose transport via PEPPyr PTS

GCCbim

glycine cleavage complex lipoylprotein irreversible mitochondrial

GLUDC

Glutamate Decarboxylase

GAPD

glyceraldehyde 3 phosphate dehydrogenase

HETZK

hydroxyethylthiazole kinase

GAPDH

Glyceraldehyde phosphate dehydrogenase

H2Ot

H2O transport via diffusion

HMPK1

hydroxymethylpyrimidine kinase ATP

ICL

Isocitrate lyase

KARA1im

acetohydroxy acid isomeroreductase mitochondrial

LDH

Lactate dehydrogenase

NDPK7

nucleoside diphosphate kinase ATPdCDP

MALS

malate synthase

MALt2r

L malate reversible transport via proton symport

LDH_D

D lactate dehydrogenase

O2t

o2 transport diffusion

O2tm

O2 transport diffusion

OCBTi

ornithine carbamoyltransferase irreversible

PFK

Phosphofructokinase

ORNTACim

ornithine transacetylase irreversible mitochondrial

PGM

Phosphoglyceromutase

ORNt3m

ornithine mitochondrial transport via proton antiport

PFL

pyruvate formate lyase

PGCD

phosphoglycerate dehydrogenase

PGI

Phosphoglucoisomerase

PGK

phosphoglycerate kinase

PGL

6 phosphogluconolactonase

PGL

6-phosphoglyconolactonase

PGM

phosphoglycerate mutase

PDGH

6-phosphoglycononate dehydrogenase

PMPK

phosphomethylpyrimidine kinase

PGPPAm_SC

phosphatidylglycerol phosphate phosphatase A yeast specific mitochondrial

PK

Pyruvate kinase

PNPase

Purine nucleoside phosphorylase

PPS

phosphoenolpyruvate synthase

PRM

Phosphoribomutase

PSERT

phosphoserine transaminase

PSP_L

phosphoserine phosphatase L serine

PTAr

phosphotransacetylase

PYRt2r

pyruvate reversible transport via proton symport

R5PI

Ribose-5-phosphate isomerase

SSALy

succinate semialdehyde dehydrogenase NADP

SUCD4

succinate dehyrdogenase

SUCOAS

succinyl CoA synthetase ADP forming

TA

Transaldolase

SUCOASm

Succinate CoA ligase ADP forming

TALA

transaldolase

TYRt2m

tyrosine mitochondrial transport via proton symport

TKII

Transketolase

TYRTAm

tyrosine transaminase mitochondrial

TKT1

transketolase

TMPPP

thiamine phosphate diphosphorylase

TMN

thiaminase

TPI

Triose phosphate isomerase

TKI

Transketolase

Xu5PE

Xylulose-5-phosphate epimerase