Table 1 Correlation analyses for structural parameters, GC%, and RNAi activity
From: A structural interpretation of the effect of GC-content on efficiency of RNA interference
Pair of measures | Pearson's correlation coefficient | Significance of correlation (p-value) | |
|---|---|---|---|
ΔGdisruption | RNAi activity | 0.2382 | 0.0165 |
siRNA GC% | RNAi activity | -0.1444 | 0.1497 |
siRNA MFE | RNAi activity | 0.0531 | 0.5982 |
Number of 3' free nts | RNAi activity | 0.0108 | 0.9146 |
Number of 5' free nts | RNAi activity | 0.0538 | 0.5933 |
Number of 3' free nts with ≥ 2 5' free nts | RNAi activity | 0.1311 | 0.2465 |
ΔGdisruption | siRNA GC% | -0.6832 | 3.519E-15 |