Profile analysis and prediction of tissue-specific CpG island methylation classes

BMC Bioinformatics

Table 3 CGI profiles: Methylation values of each non-redundant CGI profile.

	Constitutively methylated	Unmethylated in sperm	Differentially methylated	Constitutively unmethylated
Tissue/Cell type	1	2	3	4	5	6	7	8	9
CD4	0.916	0.881	0.655	0.074	0.078	0.065	0.076	0.094	0.072
CD8	0.912	0.905	0.683	0.089	0.078	0.071	0.104	0.136	0.092
DF	0.876	0.758	0.595	0.070	0.066	0.068	0.079	0.082	0.045
DK	0.866	0.708	0.531	0.077	0.061	0.063	0.072	0.074	0.086
DM	0.900	0.854	0.734	0.093	0.103	0.079	0.102	0.133	0.108
FL	0.842	0.762	0.562	0.104	0.117	0.105	0.138	0.158	0.157
FSM	0.842	0.793	0.619	0.097	0.136	0.127	0.125	0.118	0.052
HM	0.913	0.867	0.688	0.068	0.071	0.059	0.064	0.072	0.059
Liver	0.900	0.883	0.691	0.073	0.071	0.065	0.080	0.095	0.077
Placenta	0.878	0.846	0.679	0.085	0.075	0.066	0.096	0.098	0.123
SM	0.866	0.804	0.558	0.071	0.072	0.057	0.062	0.078	0.067
Sperm	0.836	0.178	0.359	0.102	0.086	0.105	0.125	0.117	0.112
Average methylation ± Std	0.879 ± 0.065	0.770 ± 0.1	0.613 ± 0.202	0.084 ± 0.066	0.085 ± 0.068	0.078 ± 0.058	0.094 ± 0.074	0.105 ± 0.088	0.088 ± 0.065

Average and tissue-specific methylation values of the nine non-redundant CGI profiles. The methylation values mentioned during the comparison of the profiles are marked in bold and all differences between profiles are supported by a MWW p-value lower than 0.01.

ISSN: 1471-2105