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Figure 2 | BMC Bioinformatics

Figure 2

From: POINeT: protein interactome with sub-network analysis and hub prioritization

Figure 2

The analysis results and downloadable items provided by POINeT. In downloadable items, (A) attr-Query has the record of the input query of genes. The table ppi-AllPPI contains all the PPIs resulting from the query. The nodes involved in ppi-AllPPI will be identified and recorded in the attr-Interactor table. The nodes with degree >= 2 are defined as mediators and recorded in the attr-Hub table. The nodes of the attr-Hub table form a network, which is denoted as ppi-Degree2. If two interactors of one interaction were both present in the attr-Query table, this interaction will be documented in ppi-QQPPI. Interactors in the ppi-QQPPI network will be recorded in the attr-QQ table. POINeT will merge ppi-QQPPI, ppi-GOPPI, and ppi-InterologsPPI into the ppi-FilteredPPI. This network contains PPIs with higher reliabilities and certain biological significances. (B) A simple PPI network is provided to illustrate the components of the network. Query nodes are marked with red circles; mediators (nodes connecting more than two nodes) other than query nodes are marked with blue circles. QQPPI are shown in black lines. GOPPI are shown in red lines. InterologousPPI are shown in green lines.

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