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Table 1 Island estimates of λ and K

From: Island method for estimating the statistical significance of profile-profile alignment scores

c

R c

SE

20

18942541

0.1924

0.02%

0.0395

21

15451236

0.1899

0.03%

0.0371

22

12673131

0.1882

0.03%

0.0354

23

10416563

0.1866

0.03%

0.0339

24

8557899

0.1846

0.03%

0.0320

25

7041327

0.1825

0.04%

0.0300

26

5794787

0.1800

0.04%

0.0278

27

4796202

0.1782

0.05%

0.0262

28

3981201

0.1767

0.05%

0.0249

29

3312692

0.1753

0.05%

0.0238

30

2761460

0.1740

0.06%

0.0227

31

2307980

0.1730

0.07%

0.0219

32

1931516

0.1720

0.07%

0.0211

33

1618724

0.1712

0.08%

0.0204

34

1358277

0.1704

0.09%

0.0198

35

1141702

0.1697

0.09%

0.0193

36

960448

0.1692

0.10%

0.0188

37

809392

0.1688

0.11%

0.0185

38

681757

0.1683

0.12%

0.0181

39

575054

0.1679

0.13%

0.0179

40

484923

0.1675

0.14%

0.0175

41

409305

0.1671

0.16%

0.0172

42

345792

0.1668

0.17%

0.0169

43

292455

0.1666

0.18%

0.0168

44

247162

0.1663

0.20%

0.0166

45

209396

0.1664

0.22%

0.0167

46

177245

0.1664

0.24%

0.0166

47

149811

0.1661

0.26%

0.0163

48

127130

0.1664

0.28%

0.0166

49

107539

0.1663

0.30%

0.0165

50

91004

0.1661

0.33%

0.0164

51

77013

0.1660

0.36%

0.0163

52

65225

0.1660

0.39%

0.0163

53

55132

0.1656

0.43%

0.0159

54

46798

0.1659

0.46%

0.0162

55

39719

0.1663

0.50%

0.0166

56

33618

0.1662

0.55%

0.0165

57

28394

0.1657

0.59%

0.0160

58

24094

0.1660

0.64%

0.0163

59

20398

0.1659

0.70%

0.0161

60

17282

0.1659

0.76%

0.0162

61

14634

0.1659

0.83%

0.0162

62

12430

0.1663

0.90%

0.0166

63

10497

0.1659

0.98%

0.0161

64

8837

0.1647

1.06%

0.0149

65

7579

0.1667

1.15%

0.0172

66

6407

0.1665

1.25%

0.0169

67

5416

0.1662

1.36%

0.0165

68

4591

0.1662

1.48%

0.0165

69

3892

0.1663

1.60%

0.0167

70

3280

0.1654

1.75%

0.0156

71

2786

0.1658

1.89%

0.0160

72

2367

0.1663

2.06%

0.0167

73

1985

0.1645

2.24%

0.0145

74

1695

0.1656

2.43%

0.0158

  1. The estimates of λ and K and the standard error (SE) in for a pair of random profiles obtained with the island method (equations 3 and 4) from 10,000 comparisons of size 1500 × 1500 using the WeightedLogOdds scoring scheme. The parameters estimated with the direct method are = 0.16636, = 0.01677.